OnabotulinumtoxinA is a protein that has been injected for decades for medicinal purposes. The product works by temporarily blocking signals to specific muscle fibers around the area of injection. This results in the relaxation of those muscles. The end result is that the skin overlying those muscles in the face does not fold onto itself, and so the wrinkles become less prominent or disappear entirely. Treatment duration varies among individuals, but generally, some effect is noticeable for between 3 to 4 months and even up to 6 months in some cases.

BOTOX^® was FDA approved in 2002 for cosmetic use to treat the vertical wrinkles between the eyebrows, often called the “elevens” because of their shape. In 2013, BOTOX^® was approved for the treatment of the wrinkles toward the sides of the eyes, sometimes referred to as “crow’s feet.” At Schmidt Facial Plastic Surgery, we also use the medication in a number of other areas to achieve a smoothing, rejuvenating, and very natural appearance to the face. These techniques are very well established but are not necessarily performed by all physicians injecting these types of medications.

We treat the following problems using BOTOX^®, Xeomin^®, and Jeuveau^®:

• horizontal wrinkles/lines of the forehead
• vertical lines between the eyebrows
• wrinkles toward the sides of the eyes (crow’s feet)
• horizontal wrinkles of the nose (sometimes called bunny lines)
• wrinkles around the lips
• excessively mobile upper lip during smile (gummy smile)
• cobblestoned or dimpled chin
• prominent neck bands (lizard neck appearance)

Other companies offer similar and effective products that contain the same or a similar protein, and these products go by a different brand names (e.g., Xeomin^® and Jeuveau^® versus BOTOX^®). The medication is extremely effective at treating wrinkles, particularly those that are only present with movement of the muscles of the face. As with most types of medical treatment, there is potential for risk. We disclose these risks while discussing your customized treatment plan.

Neuromodulators for Wrinkle Reduction in Denver, CO

Age brings insights informed by a lifetime of meaningful moments. But along with these gifts, it can also introduce visible signs that may not reflect the vibrancy you feel inside. Though fine lines like crow’s feet are completely natural, they can sometimes contribute to a fatigued or unfriendly appearance.

Fortunately, modern cosmetic treatments provide an opportunity to soften wrinkles and combat ageism while preserving your natural facial movements, letting you look as energized and confident as you feel. Double board-certified plastic surgeon Dr. Jeffrey Schmidt offers three leading neuromodulators – BOTOX^®, Xeomin^®, and Jeuveau^®  –  to refresh your appearance without sacrificing authenticity.

What Are Neuromodulators?

These injectable treatments derive from a highly purified version of the botulinum toxin. They block nerve signals to specific muscles, causing a temporary relaxation that prevents your skin from creasing when you make habitual facial expressions like frowning or squinting.

Most patients experience visible results within a few days, with effects lasting between three and six months.

BOTOX^®

BOTOX^® (OnabotulinumtoxinA) has been a trusted neuromodulator for decades, initially used for medical purposes like migraines and excessive sweating before gaining FDA approval for cosmetic applications in 2002. Quick, minimally invasive in-office injections are excellent for addressing multiple aesthetic concerns.

• 11 lines: Parallel vertical wrinkles between your eyebrows
• Crow’s feet: Smile lines that form at the outer corners of your eyes
• Forehead furrows: Horizontal wrinkles across your forehead
• Bunny lines: Fine wrinkles on the sides of your nose
• Perioral wrinkles: Small lines around your mouth
• Gummy smile: Overexposed upper gums when you smile
• Dimpled chin: Uneven, “cobblestone” texture on your chin
• Neck banding: Prominent lines along your neck

BOTOX^® offers predictable results and a proven track record, making it a preferred choice for many patients.

Xeomin^®

Xeomin^® (IncobotulinumtoxinA) is chemically similar to BOTOX^®, but with a purified formula that removes additional proteins. Some patients believe Xeomin^® feels more natural due to this refinement. This product effectively smooths wrinkles in the same treatment areas as BOTOX^®, with a few noteworthy benefits.

• Extra purification reduces the risk of resistance and allergic reactions
• Can be an effective alternative for patients who have developed a tolerance to BOTOX^®

Jeuveau

Jeuveau (PrabotulinumtoxinA-xvfs) is specifically for aesthetic applications. It is an excellent choice for patients seeking a cutting-edge solution with a smoother feel and potentially longer-lasting results.

Choose Your Neuromodulator

While all these products provide similar outcomes, the best choice depends on your goals, preferences, and previous cosmetic treatments. Whether you want a subtle refresh or a more pronounced smoothing effect, each neuromodulator offers unique benefits for your specific needs.

Dr. Schmidt takes a highly personalized approach, carefully evaluating your facial structure, muscle movement, and desired results to craft a treatment plan that enhances your natural beauty. His expertise ensures a balanced outcome – preserving your authentic facial expressions while softening lines in a way that looks effortlessly refined.

Schedule your consultation today to learn more about neuromodulator treatments. Dr. Schmidt will answer all your questions, ensure you have realistic expectations, and help you decide which option best fits your aesthetic vision.

BOTOX^® and XEOMIN^® FAQs

How much research has gone into BOTOX^®?

When you choose BOTOX^®, you can trust its track record. Backed by over 16 years of published studies, BOTOX^® is the most widely studied cosmetic treatment of its kind, approved for use in almost 100 countries. More than 500 peer-reviewed articles published in medical and scientific journals have described this product’s safety and efficacy.

Will my face look unnatural or overdone?

Neuromodulators’ long-lasting popularity has led many unqualified, untrained people to advertise their services as injectors. While getting your injectable treatment at your hair salon or a friend’s house might seem convenient, you should always choose the services of a board-certified facial plastic surgeon to ensure reliable, natural-looking results. Dr. Schmidt has a medical doctorate and has completed a highly competitive fellowship program at one of the world’s premier facial plastic surgery training institutions, and he pledges to uphold the highest standards of medical ethics and patient safety.

Are neuromodulator injections only for women?

Absolutely not. Many men are finding the benefits of BOTOX^® and XEOMIN^® to help them maintain a youthful appearance for personal and professional relationships. The number of men choosing these products has been steadily increasing in the past few years, due to the appeal of a quick, painless procedure with no downtime.

What is the best age to get treatment with BOTOX^® or XEOMIN^®?

There’s no such thing as an “ideal” age to improve your appearance. Dr. Schmidt frequently sees men and women in their late 20s and early 30s who are seeking non-surgical cosmetic help.

The truth is that everyone’s expression lines form differently, based on factors like genetics, lifestyle choices, cellular changes, reduced collagen production, and skin damage caused by free radicals from the environment.

Whenever your wrinkles start becoming a concern for you, schedule a consultation to determine whether you are a good candidate.

What’s the difference between BOTOX^® and XEOMIN^®?

Though these two products have the same active ingredient, and both work to minimize wrinkles, they have a different formulation. While BOTOX^® includes multiple protective proteins clustered around the active molecule, XEOMIN^® undergoes an extra purification step of purification that eliminates these additives.

As a “naked” form of botulinum toxin, XEOMIN^® bonds directly with your facial muscles. That’s why Dr. Schmidt often recommends it as an effective solution for anyone who has noticed their BOTOX^® injections don’t produce the same results they used to.

Connect with our office to schedule your consultation.

What’s the science behind neuromodulators?

BOTOX^® is the world’s most widely researched cosmetic neuromodulator, with decades of rigorous scientific study and clinical use. It’s received approval in nearly 100 countries. More than 500 peer-reviewed articles in medical and scientific journals confirm its safety and effectiveness, making it one of the most trusted options for facial rejuvenation.

Will my face look “frozen” or overdone?

Neuromodulators provide a subtle, natural-looking enhancement when performed by an experienced professional, never creating an overdone look or preventing you from expressing yourself. Precision and expertise are critical to delivering results you’ll be proud to show off.

Unfortunately, injectables’ widespread popularity has led some unqualified providers to offer treatments in non-medical settings like salons and day spas. For your safety, always choose a board-certified facial plastic surgeon like Dr. Schmidt, who has advanced training in facial anatomy and aesthetics. His medical doctorate and prestigious fellowship experience ensure safe, reliable, and elegant outcomes.

Are neuromodulator treatments only for women?

Not at all! Men also seek these solutions to refresh their appearance and achieve more confidence throughout their professional and personal lives. Our male patients appreciate that this procedure is brief, requires no anesthesia or incisions, and allows them to return to their usual schedule immediately afterward.

What is the best age to start treatment?

There is no universal “ideal” age for neuromodulator injections. Some people begin treatments in their late 20s or early 30s to prevent deeper wrinkles from forming, while others seek correction in their 40s and beyond.

Genetics, lifestyle, collagen production, and environmental factors influence how quickly and noticeably you age. If expression lines become a concern, schedule your private consultation with Dr. Schmidt to determine whether you’re a good candidate for neuromodulators.

What’s the difference between neuromodulators and dermal fillers?

Neuromodulators relax muscles to smooth wrinkles caused by facial movements, while dermal fillers add volume and contour. They can restore lost fullness, enhance areas like cheeks and lips, and soften static wrinkles that are visible even when the face is at rest. For optimal facial rejuvenation, some patients combine neuromodulators with fillers to achieve a balanced, refreshed appearance tailored to their unique needs.

Is there a difference in effectiveness between BOTOX^®, Xeomin^®, and Jeuveau?

Each neuromodulator works similarly, but patients may respond differently to each formulation. Some find Xeomin^® feels more natural, while others prefer Jeuveau’s modern formulation.

Does the treatment hurt?

Dr. Schmidt uses his skills to ensure you are comfortable throughout your appointment, including using a small, fine needle to perform the injections. If you prefer, you may request a topical numbing agent for additional comfort.

Are there side effects?

You may experience temporary redness, slight swelling, or mild bruising around the injection sites; these typically resolve within a few hours to a few days. Dr. Schmidt will provide full guidance on post-treatment care as part of his commitment to your safety.

Will I see my results right away?

Neuromodulators take time to work. While you might notice subtle changes within a few days, full results typically develop over the next 10 to 14 days as the targeted muscles gradually relax.

If you’re preparing for a big event like a wedding, class reunion, or professional photoshoot, it’s wise to schedule your treatment at least two weeks in advance to ensure you achieve the optimal smoothing effect in time.